Keep in mind that it's possible to develop a tolerance to CBD, like many other drugs and chemicals. So, if you find that it doesn't work as well after a while, try taking a break for a few days to reset your system before starting again on a low dose. Is it possible for patients to develop a tolerance to their medical cannabis medications? The answer is yes and no. The reason is that the tolerance profiles are different for THC and CBD, the two main active components of medical cannabis.
While frequent use of medical cannabis leads to greater tolerance to THC, the same is not the case with CBD. Building tolerance means having to take increasingly higher doses to achieve the same effects that were experienced initially. Keep in mind that developing tolerance should not be confused with physical addiction or dependence. People who drink coffee frequently will find that they must drink more to feel the same effects as when they first started drinking.
But why does the body develop a tolerance to substances in the first place? THC or tetrahydrocannabinol is the psychoactive ingredient responsible for making users feel “high”. CBD, or cannabidiol, is considered the medicinal element that has been shown to alleviate the symptoms of anxiety, chronic pain, depression and nerve pain. Unlike THC, CBD does not cause any intoxicating effects. However, THC demonstrates clear health benefits for patients suffering from pain, lack of appetite, insomnia and post-traumatic stress disorder.
The good news is that CBD doesn't seem to create a tolerance to CBD in regular users. This is because CBD and THC don't bind to CB1 receptors in the same way. As a result, when CBD binds to these receptors, they don't become desensitized. No matter what you use medical cannabis for, it's important to remember that it changes the way your body works.
Understanding these mechanisms is crucial for safe and effective cannabis use. People who frequently supplement with CBD products may develop a tolerance to CBD. This is perfectly normal and means that your body is actually working as intended. The theory within the community is that this tolerance has to do with the way in which CBD interacts with the endocannabinoid system.
Taking CBD oil can help you reverse the effects of a strong tolerance to THC, as it improves receptor effectiveness. In reality, these chemicals work very differently from each other, and the inability to develop tolerance may be another potential reason to consider CBD as a new healthy additive to your lifestyle. The assessment slowly increases your tolerance to CBD by decreasing what your body has become accustomed to over time. Reverse tolerance may indicate that the cannabinoid receptors are working and that CBD has improved its effectiveness.
In the case of reverse tolerance, the continuous use of CBD actually means that a decreasing dose is needed to achieve the same effects over time. Some researchers even suggest that CBD creates a “reverse tolerance” to CBD, meaning that patients need to take less and less over time. If you have tolerance issues or suffer from withdrawal, consult your doctor about how to give CBD a chance to help you recover. Understanding tolerance and reverse tolerance when it comes to CBD is another crucial part of your journey to wellness.
Therefore, for medical cannabis patients who rely mainly on things like CBD oil or CBD-dominant cannabis varieties, CBD tolerance is not something to worry about. If you start to notice an increase in tolerance and still want to take advantage of the many health benefits of CBD oil, there are a few methods you can use to start the process of breaking tolerance. CBD doesn't bind to cannabinoid receptors in the same way as THC; therefore, over time you won't develop a tolerance to CBD like you would with THC. CBD completely avoids the problem of tolerance and, unlike THC, which reduces cannabinoid receptors over time, CBD actually promotes greater receptor activity.
Over time, you may accumulate enough endocannabinoids so that you can use less CBD or not even need it at all. It found that “the administration of CBD did not induce side effects at a wide range of doses, including acute and chronic dosage regimens, and tolerance to CBD was not developed.”. . .
