Cannabidiol (CBD) is a compound found in cannabis that binds to two types of receptors in the brain: G-protein-coupled receptors (CB1 and CB2) and vanilloid receptors (TRPV1). CB1 and CB2 receptors are responsible for regulating cyclic AMP, while TRPV1 is an ion channel that helps the body regulate its temperature, control inflammation, and alter the perception of pain. Neuroimaging studies have also shown that CBD modulates brain activity and connectivity in areas related to psychosis and anxiety, which could explain its therapeutic effects. Unlike THC, CBD does not activate CB1 receptors. Instead, it prevents other compounds, such as THC, from binding to CB1 receptors.
This is why CBD does not have any psychoactive effects. It also reduces many of the psychoactive effects of THC, such as memory problems and anxiety. CBD has been found to directly activate the serotonin receptor 5-HT1A, which is involved in a variety of biological and neurological processes, including anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBD has been found to reduce seizures by decreasing the arousal of brain cells involved in seizures. It also has neuroprotective properties that could be useful in treating neurological diseases.
In addition, CBD has been found to temporarily inhibit enzymes that break down endocannabinoids, resulting in more endocannabinoids being produced and more cannabinoid receptors being activated. CBD has been found to be effective in treating a variety of medical conditions, including anxiety, inflammation, pain, lethargy, aging, skin and bone injuries, and other health problems. Studies have also shown that CBD can modify the dose-response effect of LSD by increasing serotonin levels in the dorsal raphe nucleus. Strains of cannabis that are high in CBD can provide the benefits of marijuana without any of the psychoactive effects.